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CRYAA Antikörper (Biotin)

CRYAA Reaktivität: Human WB, ELISA, IF, ICC Wirt: Maus Monoclonal 1H3-B8 Biotin
Produktnummer ABIN2481844
  • Target Alle CRYAA Antikörper anzeigen
    CRYAA (Crystallin, alpha A (CRYAA))
    Reaktivität
    • 45
    • 17
    • 16
    • 3
    • 1
    Human
    Wirt
    • 28
    • 17
    • 1
    Maus
    Klonalität
    • 28
    • 18
    Monoklonal
    Konjugat
    • 21
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CRYAA Antikörper ist konjugiert mit Biotin
    Applikation
    • 34
    • 26
    • 16
    • 10
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~20 kDa. Does not cross-react with αB-crystallin, βL-crystallin, ΒH- crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.
    Kreuzreaktivität
    Rind (Kuh), Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Native Alpha Crystallin
    Klon
    1H3-B8
    Isotyp
    IgG1
    Top Product
    Discover our top product CRYAA Primärantikörper
  • Applikationshinweise
    • WB (1:2000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    0.5 μg/ml was sufficient for detection of 100 ng purified alphaA crystalline by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.2, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    CRYAA (Crystallin, alpha A (CRYAA))
    Andere Bezeichnung
    Alpha A Crystallin (CRYAA Produkte)
    Synonyme
    CRYA1 antikoerper, CTRCT9 antikoerper, HSPB4 antikoerper, AI323437 antikoerper, Acry-1 antikoerper, Crya-1 antikoerper, Crya1 antikoerper, DAcry-1 antikoerper, lop18 antikoerper, alpha-a-crystallin antikoerper, cryaa-A antikoerper, CRYAA antikoerper, wu:fc06h04 antikoerper, zgc:92036 antikoerper, HspB4 antikoerper, crystallin alpha A antikoerper, crystallin, alpha A antikoerper, alphaA-crystallin antikoerper, alpha-crystallin A chain-like antikoerper, crystallin alpha A S homeolog antikoerper, alpha-crystallin A chain antikoerper, CRYAA antikoerper, Cryaa antikoerper, CpipJ_CPIJ005646 antikoerper, cryaa antikoerper, LOC100384978 antikoerper, cryaa.S antikoerper, LOC458589 antikoerper, LOC102724652 antikoerper
    Hintergrund
    The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8).
    Gen-ID
    1409
    NCBI Accession
    NP_000385
    UniProt
    P02489
    Pathways
    M Phase
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