Podoplanin Antikörper

Produktnummer ABIN2476175

Produktdetails anti-Podoplanin Antikörper

Target: Podoplanin (PDPN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Podoplanin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody recognizes Human Podoplanin (gp36), a 36 kDa type I cell membrane-associated glycoprotein, with a broad spectrum of distribution, being strongly expressed on the lymphatic endothelium found in lung, placenta and skeletal muscle and to a lesser extent in brain, kidney and liver. Podoplanin is absent on blood endothelium and therefore This antibody is readily able to distinguish between lymphatic vessels and blood vasculature. Although the specific function of this protein is undetermined, Podoplanin is reported to be a reliable indicator of tumour lymphangiogenesis.

Produktmerkmale: Purified IgG

Aufreinigung: Purified

Immunogen: ORF Human podoplanin ectodomain expressed in E.coli

Klon: 4D5aE5E6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Referenzen für anti-Podoplanin Antikörper (ABIN2476175)

Furtado, Marinkovic, Martin, Garin, Hoch, Hubner, Chen, Genden, Skobe, Lira: "Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 12, pp. 5026-31, (2007) (PubMed).

Dadras, Paul, Bertoncini, Brown, Muzikansky, Jackson, Ellwanger, Garbe, Mihm, Detmar: "Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival." in: The American journal of pathology, Vol. 162, Issue 6, pp. 1951-60, (2003) (PubMed).

Matsui, Nagy-Bojarsky, Laakkonen, Krieger, Mechtler, Uchida, Geleff, Kang, Johnson, Kerjaschki, Kang: "Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels." in: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 8, pp. 1981-9, (2003) (PubMed).

Details zu Podoplanin

Target: Podoplanin (PDPN)

Andere Bezeichnung: PODOPLANIN (PDPN Produkte)

Hintergrund: Synonyms: AGGRUS

Gen-ID: 10630

UniProt: Q86YL7

Pathways: Dicarboxylic Acid Transport