Cullin 3 Antikörper (N-Term)

Produktnummer ABIN2470220

Der Kaninchen Polyklonal Anti-Cullin 3-Antikörper wurde für WB, IHC, ELISA und IP validiert. Er ist geeignet, Cullin 3 in Proben von Human zu detektieren.

Kurzübersicht für Cullin 3 Antikörper (N-Term) (ABIN2470220)

Target: Cullin 3 (CUL3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cullin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Produktdetails anti-Cullin 3 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Delipidation and Defibrination

Immunogen: Cullin 3 antibody was raised against amino acids 1-12 from the N-Terminus of Cullin 3 (Human).

Anwendungsinformationen

Applikationshinweise: Cullin 3 antibody can be used in ELISA starting at 1:1000, and immunohistochemistry starting at 10 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 % Sodium azide

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store Cullin 3 antibody at 4 °C or -20 °C.

Details zu Cullin 3

Target: Cullin 3 (CUL3)

Andere Bezeichnung: Cullin 3

Hintergrund: Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 3 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul3 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul3 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Unlike Cul1 and Cul2, Cul3 seems not to be a part of the SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Cul3 also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.

Gen-ID: 8452

UniProt: Q13618

Pathways: M Phase