HDAC4 Antikörper (AA 194-209)

Produktnummer ABIN2470109

Der Kaninchen Polyklonal anti-HDAC4 Antikörper wird verwendet zum Nachweis von HDAC4 in Proben von Human und Maus. Er wurde validiert für WB, IHC und IP.

Kurzübersicht für HDAC4 Antikörper (AA 194-209) (ABIN2470109)

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-HDAC4 Antikörper

Bindungsspezifität: AA 194-209

Aufreinigung: Protein G Column

Immunogen: Histone Deacetylase 4 antibody was raised against amino acids 194 - 209 of Histone Deacetylase 4 (Human).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Histone Deacetylase 4 antibody can be used in immunohistochemistry starting at 10 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.05 % BSA and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Histone Deacetylase 4 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Details zu HDAC4

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Andere Bezeichnung: Histone Deacetylase 4

Hintergrund: Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93 % identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

Gen-ID: 9759

UniProt: P56524

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process