ALAS1 Antikörper (AA 480-530)

Produktnummer ABIN2470088

Der Kaninchen Polyklonal anti-ALAS1 Antikörper wird verwendet zum Nachweis von ALAS1 in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für ALAS1 Antikörper (AA 480-530) (ABIN2470088)

Target: ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALAS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ALAS1 Antikörper

Bindungsspezifität: AA 480-530

Aufreinigung: Protein G Column

Immunogen: ALAS1 antibody was raised against amino acids 480 - 530 of ALAS1 (Human).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ALAS1 antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.2 % gelatin, 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store ALAS1 antibody at 4 °C for short term applications. For long term storage, aliquot and -20 °C.

Details zu ALAS1

Target: ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))

Andere Bezeichnung: ALAS1

Hintergrund: ALAS-1 (EC 2.3.1.37) is a nuclear-encoded mitochondrial matrix enzymecatalyzing the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5 phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.

Gen-ID: 211

UniProt: P13196

Pathways: Regulation of Lipid Metabolism by PPARalpha