IL-25 Antikörper (AA 115-132)

Produktnummer ABIN2469612

Produktdetails anti-IL-25 Antikörper

Target: IL-25 (IL25) (Interleukin 25 (IL25))

Bindungsspezifität: AA 115-132

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-25 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Protein G Column

Immunogen: IL - 25 monoclonal antibody was raised against amino acids 115 - 132 of IL - 25 (Human).

Klon: 68C1039-2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: IL-25 antibody can be used in ELISA starting at 1: 10000, Western Blot starting at 1: 500 - 1: 2000, and immunohistochemistry starting at 1:200.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Product should be stored long term (months) at -20 °C and short term (weeks) at 4 °C.

Details zu IL-25

Target: IL-25 (IL25) (Interleukin 25 (IL25))

Andere Bezeichnung: IL-25 (IL25 Produkte)

Synonyme: IL17E antikoerper, IL-17e antikoerper, Il17e antikoerper, IL25 antikoerper, RGD1561632 antikoerper, interleukin 25 antikoerper, IL25 antikoerper, Il25 antikoerper

Hintergrund: Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis , multiple sclerosis , and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al and Lee, et al. and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-κ,B pathway and like IL-17 also induces production of IL-8. The IL17 proteins are a family of potent cytokines that act to induce proinflammatory responses. Studies have shown that IL17E binds strongly to IL17RB. Receptor binding of ligand has been shown to lead to the activation of nuclear factor kappa-B and production of IL8. Exposure of mice to IL17 resulted in a Th-2 like response characterized by increased serum IgE, IgG1 and IgA levels, blood eosinophilia, increased lymphocytes and neutrophils, and pathological changes in the tissues that included eosinophilic infiltrates, increased mucus production, B-lymphocyte hyperplasia and epithelial cell hyperplasia/hypertrophy.

Gen-ID: 64806

UniProt: Q9H293