Metabotropic Glutamate Receptor 5 Antikörper (N-Term)

Produktnummer ABIN2469508

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Metabotropic Glutamate Receptor 5 in IHC. Er zeigt eine Reaktivität gegenüber Ratte, Human, Maus, Huhn, Hund, Affe, Schwein, Fledermaus, Rind (Kuh), Hamster, Pferd, Kaninchen und Gibbon.

Kurzübersicht für Metabotropic Glutamate Receptor 5 Antikörper (N-Term) (ABIN2469508)

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Reaktivität: Ratte, Human, Maus, Huhn, Hund, Affe, Schwein, Fledermaus, Rind (Kuh), Hamster, Pferd, Kaninchen, Gibbon

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 5 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-Metabotropic Glutamate Receptor 5 Antikörper

Bindungsspezifität: N-Term

Spezifität: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: GRM5 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM5 (Human).

Anwendungsinformationen

Applikationshinweise: GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-80 °C

Informationen zur Lagerung: GRM5 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Details zu Metabotropic Glutamate Receptor 5

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Andere Bezeichnung: GRM5

Hintergrund: Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia

Gen-ID: 2915

UniProt: P41594

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity