MST1R Antikörper (Internal Region)

Produktnummer ABIN2469460

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MST1R in IHC. Es zeigt Reaktivität gegenüber Proben von Human, Affe, Fledermaus und Gorilla.

Kurzübersicht für MST1R Antikörper (Internal Region) (ABIN2469460)

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Reaktivität: Human, Affe, Fledermaus, Gorilla

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MST1R Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-MST1R Antikörper

Bindungsspezifität: Internal Region

Spezifität: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: MST1R antibody was raised against a peptide located near the internal domain of MST1R (Human).

Anwendungsinformationen

Applikationshinweise: MST1R antibody can be used in immunohistochemistry starting at 20 μg/mL, and immunofluorescence.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-80 °C

Informationen zur Lagerung: MST1R antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Details zu MST1R

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Andere Bezeichnung: MST1R

Hintergrund: MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers.

Gen-ID: 4486

UniProt: Q04912

Pathways: RTK Signalweg