PARL Antikörper

Produktnummer ABIN2463992

Der Kaninchen-Polyklonal Anti-PARL-Antikörper wurde für ELISA, WB und IHC validiert. Er ist geeignet zum Nachweis von PARL in Proben aus Human, Maus, Ratte und Hund. }

Kurzübersicht für PARL Antikörper (ABIN2463992)

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARL Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PARL Antikörper

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PARL.

Anwendungsinformationen

Applikationshinweise: PARL antibody can be used for detection of PARL by ELISA at 1:312500. PARL antibody can be used for detection of PARL by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PARL antibody at -20 °C.

Details zu PARL

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Andere Bezeichnung: PARL

Hintergrund: PARL is a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. PARL may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in its gene has been associated with increased risk for type 2 diabetes.This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 36 kDa, 42 kDa

Gen-ID: 55486

NCBI Accession: NP_001032728

Pathways: Autophagie