RRM1 Antikörper

Produktnummer ABIN2462920

Produktdetails anti-RRM1 Antikörper

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, C. elegans

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RRM1.

Anwendungsinformationen

Applikationshinweise: RRM1 antibody can be used for detection of RRM1 by ELISA at 1:62500. RRM1 antibody can be used for detection of RRM1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store RRM1 antibody at -20 °C.

Details zu RRM1

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Andere Bezeichnung: RRM1 (RRM1 Produkte)

Synonyme: CG5371 antikoerper, DmRNR1 antikoerper, Dmel\\CG5371 antikoerper, RNR1 antikoerper, RnrM1 antikoerper, RntL antikoerper, l(2)k06709 antikoerper, XRRM1 antikoerper, R1 antikoerper, RIR1 antikoerper, RR1 antikoerper, CHUNP6866 antikoerper, cb396 antikoerper, cb838 antikoerper, r1 antikoerper, sb:cb548 antikoerper, wu:fb39b07 antikoerper, wu:fi14b02 antikoerper, wu:fk95f07 antikoerper, ribonucleotide reductase catalytic subunit M1 antikoerper, Ribonucleoside diphosphate reductase large subunit antikoerper, ribonucleoside-diphosphate reductase large subunit antikoerper, ribonucleotide reductase M1 L homeolog antikoerper, ribonucleotide reductase M1 antikoerper, ribonucleotide reductase M1 polypeptide antikoerper, RRM1 antikoerper, RnrL antikoerper, LOC100472317 antikoerper, rrm1 antikoerper, rrm1.L antikoerper, Rrm1 antikoerper

Hintergrund: RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.

Molekulargewicht: 90 kDa

Gen-ID: 6240

NCBI Accession: NP_001024

UniProt: P23921

Pathways: Positive Regulation of Endopeptidase Activity