PRP19 Antikörper

Produktnummer ABIN2462670

Produktdetails anti-PRP19 Antikörper

Target: PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRP19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PRPF19.

Anwendungsinformationen

Applikationshinweise: PRPF19 antibody can be used for detection of PRPF19 by ELISA at 1:312500. PRPF19 antibody can be used for detection of PRPF19 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PRPF19 antibody at -20 °C.

Details zu PRP19

Target: PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

Andere Bezeichnung: PRPF19 (PRPF19 Produkte)

Synonyme: NMP200 antikoerper, fb18f09 antikoerper, zgc:56158 antikoerper, wu:fb18f09 antikoerper, nmp200 antikoerper, PRP19 antikoerper, PSO4 antikoerper, SNEV antikoerper, UBOX4 antikoerper, hPSO4 antikoerper, Prp19 antikoerper, nmp-200 antikoerper, AA617263 antikoerper, AL024362 antikoerper, D19Wsu55e antikoerper, Snev antikoerper, pre-mRNA processing factor 19 antikoerper, pre-mRNA processing factor 19 L homeolog antikoerper, prpf19 antikoerper, prpf19.L antikoerper, PRPF19 antikoerper, Prpf19 antikoerper

Hintergrund: PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.

Molekulargewicht: 55 kDa

Gen-ID: 27339

NCBI Accession: NP_055317

UniProt: Q9UMS4

Pathways: Ribonucleoprotein Complex Subunit Organization