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INSIG1 Antikörper

INSIG1 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2458475
  • Target Alle INSIG1 Antikörper anzeigen
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Reaktivität
    • 28
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 28
    Kaninchen
    Klonalität
    • 28
    Polyklonal
    Konjugat
    • 16
    • 4
    • 2
    • 2
    • 2
    • 2
    Dieser INSIG1 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 16
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    Antibody is purified by peptide affinity chromatography method.
    Immunogen
    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human INSIG1.
    Top Product
    Discover our top product INSIG1 Primärantikörper
  • Applikationshinweise
    INSIG1 antibody can be used for detection of INSIG1 by ELISA at 1:1562500. INSIG1 antibody can be used for detection of INSIG1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
    Konzentration
    1 mg/mL
    Buffer
    Antibody is lyophilized in PBS buffer with 2 % sucrose.
    Handhabung
    As with any antibody avoid repeat freeze-thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    For short periods of storage (days) store at 4 °C. For longer periods of storage, store INSIG1 antibody at -20 °C.
  • Target
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Andere Bezeichnung
    INSIG1 (INSIG1 Produkte)
    Synonyme
    cl-6 antikoerper, cl6 antikoerper, CL-6 antikoerper, CL6 antikoerper, fb55a03 antikoerper, fi35b10 antikoerper, wu:fb55a03 antikoerper, wu:fi35b10 antikoerper, zgc:55439 antikoerper, 1810013C12Rik antikoerper, Insig-1 antikoerper, INSIG-1 antikoerper, insulin induced gene 1 antikoerper, insulin induced gene 1 L homeolog antikoerper, INSIG1 antikoerper, insig1 antikoerper, insig1.L antikoerper, Insig1 antikoerper
    Hintergrund
    Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Molekulargewicht
    25 kDa
    Gen-ID
    51141
    NCBI Accession
    NP_057217
    UniProt
    Q9Y5U4
    Pathways
    ER-Nucleus Signaling
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