UNC13D Antikörper (N-Term)

Produktnummer ABIN2443930

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch UNC13D in WB und IP. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für UNC13D Antikörper (N-Term) (ABIN2443930)

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNC13D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-UNC13D Antikörper

Bindungsspezifität: AA 1-273, N-Term

Verwendungszweck: Munc13-4 Rabbit Polyclonal Antibody

Spezifität: The antibody recognizes the N-terminal of the human Munc13-4 protein (aa 1-273).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: If reconstituted with deionized water in 50 μL: WB: 1:2000, IP: native conditions. Optimal dilution has to be determined by the user.

Buffer: Lyophilized serum

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Haltbarkeit: 24 months

Details zu UNC13D

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Andere Bezeichnung: Munc13-4

Hintergrund:

Protein unc-13 homolog D, hMunc13-4, UNC13D, FHL3, HLH3, HPLH3, Munc13-4, unc-13 homolog D

Protein unc-13 homolog D (Munc13-4) is involved in cytotoxic granule exocytosis in lymphocytes. It regulates the assembly of recycling of late endosomal structures which leads to the formation of an endosomal exocytic compartment. It also regulates Ca2+-dependent secretory lysosome exocytosis in mast cells. Munc13-4 is highly expressed in the spleen, thymus and leukocytes and to a lesser extent in the lung and placenta, brain, heart, skeletal muscle and kidney. Defects in Munc13-4 are the cause of familial HL type 3 (FHL3).

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process