Presenilin 1 Antikörper (AA 21-34)

Produktnummer ABIN2443726

Dieser Maus Monoklonal Antikörper detektiert spezifisch Presenilin 1 in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Presenilin 1 Antikörper (AA 21-34) (ABIN2443726)

Target: Presenilin 1 (PSEN1)

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Presenilin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: APS11

Produktdetails anti-Presenilin 1 Antikörper

Bindungsspezifität: AA 21-34

Verwendungszweck: Presenilin 1 (C term) Mouse Monoclonal Antibody (APS11)

Spezifität: The antibody recognizes the C-terminal region of the Presenilin 1 with no cross-reactivity observed with Presenilin 2

Immunogen: aa 21-34

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA 1:200,WB 1:100,IF 1:1300,IHC 1:1300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: If reconstituted with deionized water in 250μL: ELISA 1:200, WB 1:100, IF 1:1300, IHC 1:1300. Optimal dilution has to be determined by the user.

Buffer: Lyophilized protein free tissue culture supernatant

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Haltbarkeit: 24 months

Details zu Presenilin 1

Target: Presenilin 1 (PSEN1)

Andere Bezeichnung: Presenilin 1

Hintergrund:

PS-1, Protein S182, PSEN1

Presenilin is an integral membrane protein ubiquitously expressed in the brain, it is mainly expressed in neurons where it is localized in the endoplasmic reticulum. Mutations in the presenilin proteins (PSEN1, PSEN2) are linked to an inherited form of Alzheimer's disease in some patients by increasing the production of the longer form of amyloid-beta. Presenilins are thought to affect gamma-secretase by regulating amyloid precursor protein (APP) processing and cleavage of the Notch receptor.

UniProt: P49768

Pathways: Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport