ERBB3 Antikörper

Produktnummer ABIN238335

Dieses Anti-ERBB3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ERBB3 in IHC und FACS. Geeignet für Human.

Kurzübersicht für ERBB3 Antikörper (ABIN238335)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ERBB3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: DY-7G2

Produktdetails anti-ERBB3 Antikörper

Aufreinigung: Protein G

Immunogen: genetic immunisation with cDNA encoding human ErbB-3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Kommentare:

Synonyms: Her3

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C

Informationen zur Lagerung: short term: 2 °C - 8 °C, long term: -20 °C

Details zu ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Andere Bezeichnung: ErbB3

Hintergrund: ErbB-3 belongs to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. The 148-kDa trans-membrane polypeptide ErbB-3 has a neuregulin binding domain but not an active kinase domain. Heterodimerisation with EGF receptor family members which possess kinase activity leads to the activation of pathways which indicate cell proliferation or differentiation (1). Over-expression of ErbB-3 has been reported in numerous cancers, including prostate, bladder and breast tumours.

UniProt: P21860

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung