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ELANE Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ELANE in IA. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN2192191

Kurzübersicht für ELANE Antikörper (ABIN2192191)

Target

Alle ELANE Antikörper anzeigen
ELANE (Elastase, Neutrophil Expressed (ELANE))

Reaktivität

  • 72
  • 6
  • 5
  • 2
  • 1
Human

Wirt

  • 53
  • 20
  • 5
  • 1
Kaninchen

Klonalität

  • 48
  • 31
Polyklonal

Konjugat

  • 49
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser ELANE Antikörper ist unkonjugiert

Applikation

  • 39
  • 35
  • 23
  • 12
  • 11
  • 10
  • 10
  • 5
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Immunoassay (IA)
  • Sterilität

    0.2 μm filtered
  • Applikationshinweise

    The antibody can be used in immuno assays. The antibody is not useful in immuno histology.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

    Haltbarkeit

    12 months
  • Hiltermann, Lapperre, van Bree, Steerenberg, Brahim, Sont, Sterk, Hiemstra, Stolk: "Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma." in: Free radical biology & medicine, Vol. 27, Issue 11-12, pp. 1448-54, (2000) (PubMed).

    Dentener, Francot, Hiemstra, Tool, Verhoeven, Vandenabeele, Buurman: "Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha." in: The Journal of infectious diseases, Vol. 175, Issue 1, pp. 108-17, (1997) (PubMed).

  • Target

    ELANE (Elastase, Neutrophil Expressed (ELANE))

    Andere Bezeichnung

    Leukocyte Elastase

    Hintergrund

    Leukocyte elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1- PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4.
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