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Complement C3c Antikörper (Complement Component C3c) Primary Antibody

C3C Reaktivität: Human IP Wirt: Ratte Monoclonal 4 unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2192054
$605.98
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target See all Complement C3c (C3C) products
    Complement C3c (C3C)
    Reaktivität
    • 64
    • 29
    • 19
    • 17
    • 15
    • 14
    • 8
    • 6
    • 3
    • 1
    Human
    Wirt
    • 82
    • 29
    • 12
    • 9
    • 2
    • 1
    Ratte
    Klonalität
    • 129
    • 3
    Monoklonal
    Konjugat
    • 47
    • 36
    • 16
    • 16
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Complement C3c Antikörper ist unkonjugiert
    Applikation
    • 80
    • 51
    • 33
    • 30
    • 21
    • 20
    • 17
    • 15
    • 13
    • 13
    • 11
    • 11
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Immunoprecipitation (IP)
    Sterilität
    0.2 μm filtered
    Klon
    4
  • Applikationshinweise
    of monoclonal anti-C3 antibodies to characterise the fragments of C3 that are found on erythrocytes. Vox Sang 1983, 45: 367
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Lachmann, Pangburn, Oldroyd: "Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies." in: The Journal of experimental medicine, Vol. 156, Issue 1, pp. 205-16, (1982) (PubMed).

    Lachmann, Oldroyd, Milstein, Wright: "Three rat monoclonal antibodies to human C3." in: Immunology, Vol. 41, Issue 3, pp. 503-15, (1981) (PubMed).

  • Target
    Complement C3c (C3C)
    Andere Bezeichnung
    c3c (C3C Produkte)
    Hintergrund
    The monoclonal antibody 4 recognizes the cleaved human C3 fragment C3c. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/mL. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. The monoclonal antibody 4 recognizes a conformational epitope in C3c, C3b and iC3b.
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