ELANE Antikörper

Produktnummer ABIN2192035

Produktdetails anti-ELANE Antikörper

Target: ELANE (Elastase, Neutrophil Expressed (ELANE))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ELANE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoassay (IA)

Sterilität: 0.2 μm filtered

Klon: 265-3K1

Anwendungsinformationen

Applikationshinweise: For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Details zu ELANE

Target: ELANE (Elastase, Neutrophil Expressed (ELANE))

Andere Bezeichnung: Leukocyte Elastase (ELANE Produkte)

Synonyme: ELA2 antikoerper, GE antikoerper, HLE antikoerper, HNE antikoerper, NE antikoerper, PMN-E antikoerper, SCN1 antikoerper, Ela2 antikoerper, F430011M15Rik antikoerper, ela2 antikoerper, ELANE antikoerper, elastase, neutrophil expressed antikoerper, proteinase 3 antikoerper, ELANE antikoerper, Elane antikoerper, prtn3 antikoerper

Hintergrund: The monoclonal antibody 265-3K1 recognizes human leukocyte elastase. Leukocyte elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4.