CD59 Antikörper

Produktnummer ABIN2191998

Dieses Anti-CD59-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD59 in WB, FACS, IP und Inhibition. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für CD59 Antikörper (ABIN2191998)

Target: CD59

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD59 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Antibody (Inhibition)

Klon: MEM-43

Produktdetails anti-CD59 Antikörper

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Low endotoxin level

Anwendungsinformationen

Applikationshinweise: For flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For neutralization of biological activity dilutions have to be made according to the amounts endotoxin to be inactivated.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS and 0.1 % bovine serum albumin with low endotoxin level.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-CD59 Antikörper (ABIN2191998)

Yamamoto, Nakane, Doi, Osaki: "Lipopolysaccharide signal transduction in oral keratinocytes--involvement of CD59 but not CD14." in: Cellular signalling, Vol. 15, Issue 9, pp. 861-9, (2003) (PubMed).

Details zu CD59

Target: CD59

Andere Bezeichnung: CD59

Hintergrund: The antibody is the prototypic antibody for the CD59 determinant, a PI-linked glycoprotein of 18-25 kDa, which is broadly expressed on most types of cells. The antigen is the major complement-protecting molecule of human cells. It is expressed on all leukocytes, erythrocytes and most other cell types. Binding of this antibody inhibits the complement-protecting activity of CD59. CD59 is one of the complement regulatory membrane proteins that is missing in Paroxysmal Nocturnal Haemoglobinuria (PNH). Anti CD59 reagents may be useful in the differential diagnosis of PNH type II and PNH type I. Recently a role for CD59 in LPS signal transduction has been reported in keratinocytes. The antibody reacts with well defined epitope (W40, R-53) on CD59 Molecule.

Pathways: Komplementsystem