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C1S Antikörper

C1S Reaktivität: Human IA, IHC (fro), FACS, InhA, IP, IHC (p), WB Wirt: Maus Monoclonal M81 unconjugated
Pubmed (1 reference)
Produktnummer ABIN2191986
$659.59
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle C1S Antikörper anzeigen
    C1S
    Reaktivität
    • 64
    • 18
    • 18
    • 2
    • 1
    Human
    Wirt
    • 44
    • 14
    • 5
    • 1
    Maus
    Klonalität
    • 51
    • 13
    Monoklonal
    Konjugat
    • 39
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser C1S Antikörper ist unkonjugiert
    Applikation
    • 32
    • 18
    • 17
    • 13
    • 13
    • 13
    • 11
    • 8
    • 7
    • 7
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Inhibition Assay (InhA), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    M81
  • Applikationshinweise
    For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For inhibition of C4 activation by C1s dilutions have to be made according to the amounts C1s to be inactivated.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.1 % bovine serum albumin.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Matsumoto, Nagaki, Kitamura, Kuramitsu, Nagasawa, Seya: "Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 8, pp. 2743-50, (1989) (PubMed).

  • Target
    C1S
    Andere Bezeichnung
    c1s (C1S Produkte)
    Synonyme
    AA959438, AI255193, AI327365, C1sa, r-gsp, C1S, complement C1s, complement component 1, s subcomponent 1, complement component 1, s subcomponent, complement component 1, s subcomponent L homeolog, complement C1s subcomponent, C1S, C1s1, C1s, c1s, c1s.L, LOC100558615
    Hintergrund
    Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M81 blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.
    Pathways
    Komplementsystem
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