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C3 Antikörper (Complement Component 3) Primary Antibody

C3 Reaktivität: Human IA, FACS, WB Wirt: Maus Monoclonal 755 unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2191942
$605.98
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle C3 Antikörper anzeigen
    C3
    Reaktivität
    • 109
    • 57
    • 36
    • 7
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    Human
    Wirt
    • 71
    • 58
    • 35
    • 8
    • 8
    • 7
    Maus
    Klonalität
    • 142
    • 44
    Monoklonal
    Konjugat
    • 93
    • 25
    • 25
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser C3 Antikörper ist unkonjugiert
    Applikation
    • 94
    • 63
    • 44
    • 37
    • 34
    • 34
    • 29
    • 28
    • 26
    • 19
    • 16
    • 13
    • 12
    • 9
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunoassay (IA), Flow Cytometry (FACS), Western Blotting (WB)
    Kreuzreaktivität (Details)
    Cross reactivity: Human C3a : No
    Sterilität
    0.2 μm filtered
    Klon
    755
    Isotyp
    IgG1
  • Applikationshinweise
    For Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive Human serum control Negative C3 deficient serum control
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Hawlisch, Meyer zu Vilsendorf, Bautsch, Klos, Köhl: "Guinea pig C3 specific rabbit single chain Fv antibodies from bone marrow, spleen and blood derived phage libraries." in: Journal of immunological methods, Vol. 236, Issue 1-2, pp. 117-31, (2000) (PubMed).

    Klos, Ihrig, Messner, Grabbe, Bitter-Suermann: "Detection of native human complement components C3 and C5 and their primary activation peptides C3a and C5a (anaphylatoxic peptides) by ELISAs with monoclonal antibodies." in: Journal of immunological methods, Vol. 111, Issue 2, pp. 241-52, (1988) (PubMed).

  • Target
    C3
    Andere Bezeichnung
    c3/c3b (C3 Produkte)
    Synonyme
    AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, AI255234, HSE-MSF, Plp, C3, C3-1, sb:cb26, si:dkey-76b14.4, wu:fi34b03, wu:fj86e11, C3d, asp, cpamd1, c3, complement C3, complement component 3, complement component c3a, duplicate 1, complement component 3 L homeolog, complement component C3, complement C3-like, C3, c3a.1, c3.L, LOC443475, c3, c3-1, LOC100060539
    Hintergrund
    The monoclonal antibody 755 recognizes an epitope located in the C-terminal 360 amino acids on the alpha chain of C3, thereby recognizing C3b and full C3. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/mL. An inherited deficiency of C3 predisposes a person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody- mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. After activation of the complement system, certain enzymes become active, resulting in the cleavage of C3 into C3b and the anaphylatoxin C3a. C3b becomes attached to immune complexes and is further cleaved into iC3b, C3c, C3dg and C3f. Within the alternative pathway of complement, C3b plays a critical role in the amplification loop initiated by spontaneous hydrolysis of C3. Aliases Complement component 3 Immunogen Native C3
    Pathways
    Komplementsystem, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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