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Mannose Receptor Antikörper

MR Reaktivität: Human FACS, Func Wirt: Maus Monoclonal 15-2 unconjugated
Produktnummer ABIN2191921
  • Target Alle Mannose Receptor (MR) Antikörper anzeigen
    Mannose Receptor (MR)
    Reaktivität
    • 30
    • 23
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    Human
    Wirt
    • 23
    • 9
    • 8
    Maus
    Klonalität
    • 25
    • 15
    Monoklonal
    Konjugat
    • 15
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Mannose Receptor Antikörper ist unkonjugiert
    Applikation
    • 20
    • 17
    • 10
    • 9
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func)
    Kreuzreaktivität (Details)
    Cross reactivity: : No,t tested
    Sterilität
    0.2 μm filtered
    Klon
    15-2
    Isotyp
    IgG1
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  • Applikationshinweise
    For immunohistochemistry, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Macrophages control Negative Lymphocytes, Monocytes control
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Target
    Mannose Receptor (MR)
    Andere Bezeichnung
    Mannose Receptor, CD206 (MR Produkte)
    Synonyme
    CD206 antikoerper, CLEC13D antikoerper, CLEC13DL antikoerper, MMR antikoerper, MRC1L1 antikoerper, bA541I19.1 antikoerper, AW259686 antikoerper, MR antikoerper, mannose receptor C-type 1 antikoerper, mannose receptor, C type 1 antikoerper, MRC1 antikoerper, Mrc1 antikoerper
    Hintergrund
    The monoclonal antibody 15-2 recognizes the mannose receptor (MR), also known as CD206, a member of the vertebrate C-type lectin family. The mannose receptor, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 175 kDa single-pass type I transmembrane receptor consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR binds high-mannose structures on a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The monoclonal antibody 15-2 prevents binding of glycoproteins including t-PA to MR. Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific. Aliases MRC1, CLEC13D, MMR Immunogen Purified human mannose receptor from human placental tissue
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