Mannose Receptor Antikörper (AA 1-200)

Produktnummer ABIN7858610

Dieser Maus Monoklonal Antikörper detektiert spezifisch Mannose Receptor . Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Mannose Receptor Antikörper (AA 1-200) (ABIN7858610)

Target: Mannose Receptor (MR)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Mannose Receptor Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Klon: MRC1-9454

Produktdetails anti-Mannose Receptor Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: Mannose Receptor / CD206 (Marker of M2 Macrophages) Antibody

Spezifität: CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 1-200) of human MRC1 protein (exact sequence is proprietary)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu Mannose Receptor

Target: Mannose Receptor (MR)

Andere Bezeichnung: Mannose Receptor

Hintergrund: C-type lectin domain family 13 member D, human mannose receptor, macrophage mannose receptor 1-like protein 1, mannose receptor, C type 1-like 1

Molekulargewicht: ~170kDa

Gen-ID: 4360, 75182

UniProt: P22897