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Vitronectin Antikörper (VTN) Primary Antibody

VTN Reaktivität: Human IA, FACS, IF, IP, WB Wirt: Maus Monoclonal BV1 unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2191905
$605.98
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle Vitronectin (VTN) Antikörper anzeigen
    Vitronectin (VTN)
    Reaktivität
    • 122
    • 42
    • 33
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 112
    • 30
    • 4
    • 1
    • 1
    Maus
    Klonalität
    • 115
    • 36
    Monoklonal
    Konjugat
    • 84
    • 15
    • 11
    • 9
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Vitronectin Antikörper ist unkonjugiert
    Applikation
    • 99
    • 67
    • 49
    • 28
    • 15
    • 14
    • 13
    • 11
    • 10
    • 9
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunoassay (IA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    BV1
  • Applikationshinweise
    For flow cytometry, immunofluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Martìn-Padura, De Castellarnau, Uccini, Pilozzi, Natali, Nicotra, Ughi, Azzolini, Dejana, Ruco: "Expression of VE (vascular endothelial)-cadherin and other endothelial-specific markers in haemangiomas." in: The Journal of pathology, Vol. 175, Issue 1, pp. 51-7, (1995) (PubMed).

    Zanetti, Conforti, Hess, Martìn-Padura, Ghibaudi, Preissner, Dejana: "Clustering of vitronectin and RGD peptides on microspheres leads to engagement of integrins on the luminal aspect of endothelial cell membrane." in: Blood, Vol. 84, Issue 4, pp. 1116-23, (1994) (PubMed).

  • Target
    Vitronectin (VTN)
    Andere Bezeichnung
    Vitronectin (VTN Produkte)
    Synonyme
    VTN, DKFZp470F0511, LOC100228142, vtn, zgc:112277, V75, VN, VNT, AI256434, Vn, Aa1018, vitronectin, vitronectin a, vitronectin b, vitronectin L homeolog, VTN, vtn, vtna, vtnb, CpipJ_CPIJ016691, vtn.L, Vtn
    Hintergrund
    Monoclonal antibody BV1 recognizes human vitronectin. Vitronectin is an abundant glycoprotein (~75 kDa), consisting of 459 amino acids. About one third of the protein molecular mass is composed of carbohydrates. Vitronectin is found in blood plasma and the extracellular matrix. Vitronectin is a multifunctional protein, since it promotes attachment and spreading of animal cells in vitro, it inhibits cytolysis by the complement C5b-9 complex, and it modulates antithrombin III-thrombin action in blood coagulation. The protein consists of three domains: the N-terminal Somatomedin B domain (1-39), a central domain with hemopexin homology (131-342) and a C-terminal domain (347-459) also with hemopexin homology. The Somatomedin B domain binds to Plasminogen Activator Inhibitor-1 (PAI-1) and is responsible for PAI-1 stabilization. Furthermore, the Somatomedin B domain can also interact with the urokinase plasminogen activator receptor (uPAR). Vitronectin-uPAR interaction is required and sufficient to initiate downstream changes in cell morphology, migration and signal transduction. High plasma levels of both PAI-1 and uPAR have been shown to correlate with a negative prognosis for cancer patients. Additionally, vitronectin is a component of platelets and is as such involved in hemostasis. Amino acid 45-47 (RGD) are capable of binding to membrane bound integrins, which serve to anchor cells to the extracellular matrix. Vitronectin in plasma is an inactive monomer form. In contrast, tissue vitronectin is an active multimeric form and is able to interact with various matrix ligands like proteoglycans and collagen. Mice with a genetic deletion of vitronectin show delayed wound healing, suggesting an important role of vitronectin in tissue remodeling after injury. The monoclonal antibody BV1 binds to soluble vitronectin as well as to membrane bound vitronectin. Aliases Serum spreading factor, complement S-protein
    Pathways
    Autophagie, Smooth Muscle Cell Migration
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