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Myeloperoxidase Antikörper

MPO Reaktivität: Maus IA Wirt: Maus Monoclonal 8F4 unconjugated
Produktnummer ABIN2191797
  • Target Alle Myeloperoxidase (MPO) Antikörper anzeigen
    Myeloperoxidase (MPO)
    Reaktivität
    • 175
    • 63
    • 56
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 132
    • 77
    • 1
    • 1
    • 1
    Maus
    Klonalität
    • 121
    • 91
    Monoklonal
    Konjugat
    • 92
    • 32
    • 30
    • 12
    • 10
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Myeloperoxidase Antikörper ist unkonjugiert
    Applikation
    • 124
    • 86
    • 63
    • 62
    • 33
    • 29
    • 27
    • 19
    • 16
    • 14
    • 14
    • 13
    • 10
    • 7
    • 7
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunoassay (IA)
    Kreuzreaktivität (Details)
    Cross reactivity: Rat MPO : Yes
    Sterilität
    0.2 μm filtered
    Klon
    8F4
    Isotyp
    IgG1
    Top Product
    Discover our top product MPO Primärantikörper
  • Applikationshinweise
    For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50 Positive Neutrophils isolated from digested infarcts control 1
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Matthijsen, Huugen, Hoebers, de Vries, Peutz-Kootstra, Aratani, Daha, Tervaert, Buurman, Heeringa: "Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion." in: The American journal of pathology, Vol. 171, Issue 6, pp. 1743-52, (2007) (PubMed).

    van Leeuwen, Gijbels, Duijvestijn, Smook, van de Gaar, Heeringa, de Winther, Tervaert: "Accumulation of myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR-/- mice." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 1, pp. 84-9, (2007) (PubMed).

    Wang, DCosta, Civin, Friedman: "C/EBPalpha directs monocytic commitment of primary myeloid progenitors." in: Blood, Vol. 108, Issue 4, pp. 1223-9, (2006) (PubMed).

    Huugen, Xiao, van Esch, Falk, Peutz-Kootstra, Buurman, Tervaert, Jennette, Heeringa: "Aggravation of anti-myeloperoxidase antibody-induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor-alpha." in: The American journal of pathology, Vol. 167, Issue 1, pp. 47-58, (2005) (PubMed).

  • Target
    Myeloperoxidase (MPO)
    Andere Bezeichnung
    Myeloperoxidase (MPO Produkte)
    Synonyme
    mKIAA4033 antikoerper, MPO antikoerper, LOC100335032 antikoerper, POX2' antikoerper, XPOX2' antikoerper, mpo antikoerper, mpo-A antikoerper, pmr-1 antikoerper, pmr1 antikoerper, pox2 antikoerper, xpox2 antikoerper, myeloperoxidase antikoerper, myeloperoxidase L homeolog antikoerper, MPO antikoerper, Mpo antikoerper, LOC100335032 antikoerper, mpo.L antikoerper
    Hintergrund
    The monoclonal antibody 8F4 recognizes mouse myeloperoxidase (MPO). MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150 kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa. MPO is stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms. Involvement of MPO has been described in several human diseases, such as cardiovascular disease, airway inflammation, lung cancer, Alzheimer's disease and multiple sclerosis. A positive correlation between elevated MPO levels in serum and cardiovascular disease suggest an interesting role for MPO as an diagnostic marker, making it possible to identify patients at risk for future cardiac events. Furthermore, there are some autoimmune diseases, in which MPO is targeted by antineutrophil cytoplasm antibodies. Studies with MPO-knockout mice have shown an increased susceptibility to pneumonia following intratracheal infections. Moreover, MPO deficient mice are more susceptible to experimental autoimmune encephalitis, a T cell-dependent neuronal disease, and have an increased expression of arteriosclerotic plaques compared to wild-type mice. The anti-mouse MPO monoclonal antibody 8F4 recognizes natural MPO in biological solutions by ELISA, in frozen tissue sections fixed with acetone and in flow cytometry using a cell permeabilization method. The antibody 8F4 is cross-reactive with rat MPO. Immunogen purified mouse MPO from WEHI-3 cells
    Pathways
    Chromatin Binding
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