CCL2 Antikörper

Produktnummer ABIN2191758

Dieses Anti-CCL2-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von CCL2 in WB, IHC (p) und FACS. Geeignet für Maus. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für CCL2 Antikörper (ABIN2191758)

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CCL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: ECE-2

Produktdetails anti-CCL2 Antikörper

Kreuzreaktivität (Details): Cross reactivity: Human : No

Sterilität: 0.2 μm filtered

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: For immunohistochemistry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Referenzen für anti-CCL2 Antikörper (ABIN2191758)

Tieu, Lee, Sun, Lejeune, Recinos, Ju, Spratt, Guo, Milewicz, Tilton, Brasier: "An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice." in: The Journal of clinical investigation, Vol. 119, Issue 12, pp. 3637-51, (2009) (PubMed).

Kimura, Sumiyoshi, Samukawa, Satake, Sakanaka: "Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism." in: European journal of pharmacology, Vol. 584, Issue 2-3, pp. 415-23, (2008) (PubMed).

Zoja, Liu, Donadelli, Abbate, Testa, Corna, Taraboletti, Vecchi, Dong, Rollins, Bertani, Remuzzi: "Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice." in: Journal of the American Society of Nephrology : JASN, Vol. 8, Issue 5, pp. 720-9, (1997) (PubMed).

Details zu CCL2

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Andere Bezeichnung: Monocyte Chemoattractant Protein 1

Hintergrund: The monoclonal antibody ECE.2 recognizes mouse monocyte chemoattractant protein 1 (MCP-1). The murine JE gene encodes the monocyte-specific cytokine monocyte chemotactic protein 1 (MCP- 1). MCP-1 is a CC chemokine of 76 amino acids (~11 kDa) and is chemotactic for monocytes and basophils but not neutrophils and eosinophils. MCP-1 is expressed by smooth muscle cells (SMC), macrophages, endothelial cells, keratinocytes and fibroblasts in response to inflammatory stimuli such as interleukin 1β and tumor necrosis factor α. MCP-1 has been implicated in a variety of inflammatory processes, including inflammatory bowel disease, rheumatoid arthritis, asthma, nephritis, and parasitic and viral infections. MCP-1 antigen is not detected in the endothelium or SMC of normal arteries. MCP-1 has also been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer) MCP-1 signals via the CCR2 receptor, and is critical for aneurysm formation because of its

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion