Interferon gamma Antikörper

Produktnummer ABIN2191745

Der Ratte Monoklonal Anti-Interferon gamma-Antikörper wurde für IP, IA und Purif validiert. Er ist geeignet, Interferon gamma in Proben von Maus zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für Interferon gamma Antikörper (ABIN2191745)

Target: Interferon gamma (IFNG)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Interferon gamma Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Immunoassay (IA), Purification (Purif)

Klon: F1

Produktdetails anti-Interferon gamma Antikörper

Sterilität: 0.2 μm filtered

Anwendungsinformationen

Applikationshinweise: The antibody can be used for the purification or immunochemical investigation of mouse gamma Interferon and structural studies. Furthermore the antibody is useful for immunoprecipitation and as a tracer antibody in immuno assay procedures.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Repeated freeze and thaw cycles will cause loss of activity. Under recommended storage conditions, product is stable for one year.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Store stock solution in aliquots at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-Interferon gamma Antikörper (ABIN2191745)

Billiau, Heremans, Vandekerckhove, Dillen: "Anti-interferon-gamma antibody protects mice against the generalized Shwartzman reaction." in: European journal of immunology, Vol. 17, Issue 12, pp. 1851-4, (1988) (PubMed).

Dijkmans, Heremans, Billiau: "Heterogeneity of Chinese hamster ovary cell-produced recombinant murine interferon-gamma." in: The Journal of biological chemistry, Vol. 262, Issue 6, pp. 2528-35, (1987) (PubMed).

Heremans, Dijkmans, Sobis, Vandekerckhove, Billiau: "Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 138, Issue 12, pp. 4175-9, (1987) (PubMed).

Jacob, van der Meide, McDevitt: "In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon." in: The Journal of experimental medicine, Vol. 166, Issue 3, pp. 798-803, (1987) (PubMed).

van Tiel, Boere, Vinjé, Harmsen, Benaissa-Trouw, Kraaijeveld, Snippe: "Detection of Semliki Forest virus in cell culture by use of an enzyme immunoassay with peroxidase-labeled monoclonal antibodies specific for glycoproteins E1 and E2." in: Journal of clinical microbiology, Vol. 20, Issue 3, pp. 387-90, (1984) (PubMed).

Details zu Interferon gamma

Target: Interferon gamma (IFNG)

Andere Bezeichnung: gamma Interferon

Hintergrund: Monoclonal antibody F1 binds both natural and recombinant mouse gamma Interferon. Its binding activity has been demonstrated in vitro and in vivo. F1 antibodies have been demonstrated to be able to inhibit inflammatory responses to bacterial lipopolysaccharides. These antibodies were furthermore shown to inhibit Shwartzman reactions and to protect NZB mice against spontaneous development of autoimmune disease. The neutralizing activity of the antibody has been demonstrated as being poor in anti-viral assays. If a neutralizing antibody is specifically desired, we recommend the use of another antibody available from Hycult Biotech, namely F3 (prod. code HM1005) which recognizes a different epitope on the murine gamma Interferon molecule and in contrast to F1, exhibits strong neutralizing activity. The antibody does not react with rat or human gamma interferon.

Pathways: Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie