C5 Antikörper (N-Term)

Produktnummer ABIN206662

Dieses Maus Monoklonal-Antikörper erkennt spezifisch C5 in WB, ELISA und Func. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für C5 Antikörper (N-Term) (ABIN206662)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Functional Studies (Func)

Klon: 046-10-2-2 (10-04)

Produktdetails anti-C5 Antikörper

Bindungsspezifität: N-Term

Spezifität: Recognizes secreted complement component 5 (C5), a 190kD serine protease present in blood serum. It is composed of an 115kD disulphide linked alpha-chain and a 75 kD beta-chain. In addition to its role in complement, C5 is thought to be associated with inflammation, stimulating tumor necrosis factor alpha, interferon gamma mediated suppression of IL10 and IL12 production. C5 is activated via either the classical or the alternative complement pathway, by proteolytic cleavage of C5a from the N-terminal of the alpha-chain, by C5 convertase. C5a is an anaphylatoxin which mediates local inflammation. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. It also stimulates chemotaxis of neutrophils, eosinophils, basophils and monocytes towards the site of inflammation. The remaining fragment, C5b, initiates the assembly of the membrane attack complex. In hemolysis inhibition studies it was found that Will block C5 hemolytic activity. Removal of sodium azide is recommended prior to use in functional assays. XXX XXX recommend the use of EUQOO3 for this purpose.

Aufreinigung: Protein A purified

Immunogen: Purified human C5.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Borate buffered saline, 0.1 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Details zu C5

Target: C5 (Complement Component 5 (C5))

Andere Bezeichnung: Complement C5

Hintergrund: Name/Gene ID: C5

Synonyms: C5, Anaphylatoxin C5a analog, CPAMD4, Complement C5, Complement component 5

Gen-ID: 727

UniProt: P01031

Pathways: Komplementsystem, Carbohydrate Homeostasis