Clusterin Antikörper

Produktnummer ABIN205727

Der Kaninchen Polyklonal anti-Clusterin Antikörper wird verwendet zum Nachweis von Clusterin in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für Clusterin Antikörper (ABIN205727)

Target: Clusterin (CLU)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Clusterin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Clusterin Antikörper

Spezifität: Recognizes human clusterin, also known as apolipoprotein J, Ku70-binding protein 1 or TRPM-2. Clusterin is a ubiquitous glycoprotein which exists in at least two distinct isoforms, a proapoptotic nuclear form, of 49kD, and a prosurvival secretory form with a molecular weight of 75-80kD. Clusterin is implicated in several diverse physiological processes including sperm maturation, cell differentiation, and apoptosis. Clusterin upregulation has been reported in various human malignancies, including bladder, prostate, and breast tumors. Following specific stress induced injury, secretory clusterin acts as a molecular chaperone, scavenging denatured proteins outside cells. It has been shown to be upregulated in Alzheimer's€™s disease (Chen et al. 2012), retinitis pigmentosa (Jobes et al 1993), glomerulonephritis, atherosclerosis and myocardial infarction (Rosenberg et al. 2002).

Aufreinigung: Purified

Immunogen: Recombinant human clusterin isoform 1.

Type of Immunogen: Recombinant protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: WB (0.5 - 1 μg/mL)

Usage: Western Blot: LS-C42331 detects a band of approximately 60kD in human brain tissue lysate.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu Clusterin

Target: Clusterin (CLU)

Andere Bezeichnung: CLU / Clusterin

Hintergrund: Name/Gene ID: CLU

Synonyms: CLU, APO-J, Apolipoprotein J, CLU1, Clusterin, Complement lysis inhibitor, CLI, AAG4, Aging-associated protein 4, Ku70-binding protein 1, KUB1, SGP2, APOJ, SGP-2, Sulfated glycoprotein 2, CLU2, Complement cytolysis inhibitor, NA1/NA2, SP-40

Gen-ID: 1191

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling