beta Amyloid Antikörper

Produktnummer ABIN1990945

Dieser Maus Monoklonal Antikörper detektiert spezifisch beta Amyloid in ELISA, DB und IL. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für beta Amyloid Antikörper (ABIN1990945)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: ELISA, Dot Blot (DB), Immunolocalization (IL)

Klon: 3E5-F8

Produktdetails anti-beta Amyloid Antikörper

Verwendungszweck: Anti-mAB-O | Mouse anti-human Abeta protein (3-10) region, oligomer-specific (clone 3E5,F8)

Kreuzreaktivität (Details): Human
Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Homologie: Mouse,Bovine,Chicken,Dog,Porcine,Rabbit

Aufreinigung: Immunogen affinity purified serum

Immunogen: Synthetic peptide chosen from human Abeta (1-42) protein.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: 10 μg/mL (IL), 1-2 μg/mL (Dot), 1 μg/mL (ELISA capture)

Kommentare:

Immunolocalization: human tissue was paraffin-embedded and sectioned. De-waxed and rehydrated in an ethanol gradient. Antigens were retrieved in sodium citrate buffer (pH 6) at 95°C for 1 h. The tissue sections were separately incubated for 1 h at RT with primary antibody and antibody binding was visualized with IgG Preoxidase Reagent Kit.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: For reconstitution add 50 μL of sterile water

Buffer: Immunogen affinity purified serum in PBS pH 7.4.

Handhabung: Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube

Lagerung: -20 °C

Informationen zur Lagerung: Store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Abeta

Hintergrund: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of the amyloid precursor protein. Recent findings however suggest that smaller oligomeric forms of Abeta, formed in parallel to the amyloid plaques, excert the predominant tissue damaging effect.Specific identification of the oligomeric forms is as a consequence of great interest. Based on a recently published technique a highly oligomer-specific antibody (mAB-O), targeting Abeta oligomers while omitting reactivity towards the monomeric and fibrillar counterpart, has been developed.

Molekulargewicht: 4.5 kDa

Pathways: Inflammasome