CD161 Antikörper

Produktnummer ABIN1981864

Dieser Maus Monoklonal Antikörper detektiert spezifisch CD161 in FACS, WB und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human und Non-Human Primate. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für CD161 Antikörper (ABIN1981864)

Target: CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD161 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: HP-3G10

Produktdetails anti-CD161 Antikörper

Verwendungszweck: Anti-Hu CD161 Purified

Kreuzreaktivität (Details): Human, Non-Human Primates

Produktmerkmale: The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: human NK cells

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-CD161 Antikörper (ABIN1981864)

Tresoldi, DellAlbani, Stabilini, Jofra, Valle, Gagliani, Bondanza, Roncarolo, Battaglia: "Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells." in: Haematologica, Vol. 96, Issue 9, pp. 1357-65, (2011) (PubMed).

Germain, Meier, Jensen, Knapnougel, Poupon, Lazzari, Neisig, Håkansson, Dong, Wagtmann, Galsgaard, Spee, Braud: "Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-? contributes to modulate immune responses." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 37964-75, (2011) (PubMed).

Goetzl, Huang, Kon, Patel, Schwartz, Fast, Ferrucci, Madara, Taub, Longo: "Gender specificity of altered human immune cytokine profiles in aging." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 9, pp. 3580-9, (2010) (PubMed).

Pozo, Valés-Gómez, Mavaddat, Williamson, Chisholm, Reyburn: "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 4, pp. 2397-406, (2006) (PubMed).

Details zu CD161

Target: CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))

Andere Bezeichnung: CD161

Hintergrund: Killer cell lectin like receptor B1,CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.,NKRP1A, KLRB1, CLEC5B

Gen-ID: 3820

UniProt: Q12918