PTK2B Antikörper (PTK2B Protein tyrosine Kinase 2 beta) (pTyr402)

Details for Product anti-PTK2B Antibody No. ABIN196952
Target
Bindungsspezifität
pTyr402
28
20
15
15
12
10
10
9
8
7
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
193
141
120
9
8
8
8
6
5
4
2
2
2
1
1
Wirt
Kaninchen
173
20
3
Klonalität
Polyklonal
Konjugat
Dieser PTK2B Antikörper ist unkonjugiert
13
9
7
6
6
6
6
6
6
3
3
3
3
3
2
2
2
Applikation
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
129
76
75
39
38
13
9
6
3
3
3
1
1
1
Optionen
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Pyk2 around the phosphorylation site of tyrosine 402 (D-I-YP-A-E).
Spezifität This antibody detects endogenous levels of Pyk2 only when phosphorylated at Tyrosine 402.
Reinigung Immunoaffinity Chromatography using epitope-specific phosphopeptide.
Target
Andere Bezeichnung FAK2 / PTK2B (PTK2B Antibody Abstract)
Hintergrund PYK2 is involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. PKY2 may represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. PYK2 activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity.Synonyms: CADTK, CAK-beta, Calcium-dependent tyrosine kinase, Cell adhesion kinase beta, Focal adhesion kinase 2, PYK2, Proline-rich tyrosine kinase 2, Protein tyrosine kinase 2 beta, RAFTK, Related adhesion focal tyrosine kinase
Gen-ID 2185
NCBI Accession NP_004094
UniProt Q14289
Pathways EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
Applikations-hinweise Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Store the antibody (in aliquots) at -20 °C.
Bilder
Image no. 1 for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (ABIN196952) anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (Image 1)
Image no. 2 for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (ABIN196952) anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (Image 2)
Image no. 3 for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (ABIN196952) anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (Image 3)