PTK2B Antikörper (PTK2B Protein tyrosine Kinase 2 beta) (pTyr402)

Details for Product anti-PTK2B Antibody No. ABIN196952
Antigen
  • CADTK
  • CAKB
  • FADK2
  • FAK2
  • PKB
  • PTK
  • PYK2
  • RAFTK
  • CAKbeta
  • E430023O05Rik
  • Raftk
  • Pyk2
  • fak1b
  • ptk2.2
  • ptk2b
  • si:ch1073-355e8.1
  • protein tyrosine kinase 2 beta
  • PTK2 protein tyrosine kinase 2 beta
  • protein tyrosine kinase 2aa
  • PTK2B
  • Ptk2b
  • ptk2aa
Epitop
pTyr402
53
32
29
23
15
15
10
9
8
7
7
7
7
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
319
217
184
12
11
9
8
7
6
5
2
1
1
1
Wirt
Kaninchen
285
36
3
Klonalität
Polyklonal
Konjugat
Dieser PTK2B Antikörper ist unkonjugiert
13
9
9
9
9
9
9
7
6
3
3
3
3
3
2
2
2
Applikation
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
223
143
125
56
39
21
17
5
3
3
1
1
1
Optionen
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Pyk2 around the phosphorylation site of tyrosine 402 (D-I-YP-A-E).
Spezifität This antibody detects endogenous levels of Pyk2 only when phosphorylated at Tyrosine 402.
Reinigung Immunoaffinity Chromatography using epitope-specific phosphopeptide.
Plasmids, Primers & others Plasmide, Primers & weitere PTK2B products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung FAK2 / PTK2B (PTK2B Antibody Abstract)
Hintergrund PYK2 is involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. PKY2 may represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. PYK2 activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity.Synonyms: CADTK, CAK-beta, Calcium-dependent tyrosine kinase, Cell adhesion kinase beta, Focal adhesion kinase 2, PYK2, Proline-rich tyrosine kinase 2, Protein tyrosine kinase 2 beta, RAFTK, Related adhesion focal tyrosine kinase
Gen-ID 2185
NCBI Accession NP_004094
UniProt Q14289
Pathways EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
Applikations-hinweise Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Store the antibody (in aliquots) at -20 °C.
Bilder des Herstellers
Image no. 1 for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (ABIN196952) anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (Image 1)
Image no. 2 for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (ABIN196952) anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (Image 2)
Image no. 3 for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (ABIN196952) anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody (Image 3)
Allgemeine Veröffentlichungen Krishnan, Sharma-Walia, Streblow, Naranatt, Chandran: "Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells." in: Journal of virology, Vol. 80, Issue 3, pp. 1167-80, 2006 (PubMed).

Gluck: "Acid sensing in renal epithelial cells." in: The Journal of clinical investigation, Vol. 114, Issue 12, pp. 1696-9, 2004 (PubMed).

Tian, Litvak, Toledo-Rodriguez, Carmon, Lev: "Nir2, a novel regulator of cell morphogenesis." in: Molecular and cellular biology, Vol. 22, Issue 8, pp. 2650-62, 2002 (PubMed).

Benzing, Gerke, Höpker, Hildebrandt, Kim, Walz: "Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 17, pp. 9784-9, 2001 (PubMed).

Lu, Jiang, Blume-Jensen, Hunter: "Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase." in: Molecular and cellular biology, Vol. 21, Issue 12, pp. 4016-31, 2001 (PubMed).

Haben Sie etwas anderes gesucht?