HEXIM1 Antikörper

Produktnummer ABIN1944936

Dieses Anti-HEXIM1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HEXIM1 in WB und IF. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für HEXIM1 Antikörper (ABIN1944936)

Target: HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HEXIM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-HEXIM1 Antikörper

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF: 1:100. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-HEXIM1 Antikörper (ABIN1944936)

Wittmann, Wang, Montano: "Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors." in: Cancer research, Vol. 63, Issue 16, pp. 5151-8, (2003) (PubMed).

Ouchida, Kusuhara, Shimizu, Hisada, Makino, Morimoto, Handa, Ohsuzu, Tanaka: "Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 8, Issue 2, pp. 95-107, (2003) (PubMed).

Yik, Chen, Nishimura, Jennings, Link, Zhou: "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA." in: Molecular cell, Vol. 12, Issue 4, pp. 971-82, (2003) (PubMed).

Details zu HEXIM1

Target: HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

Andere Bezeichnung: HEXIM1

Hintergrund: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.

Molekulargewicht: 40623 Da

Gen-ID: 10614

UniProt: O94992