ErbB2/Her2 Antikörper (pSer1107)

Produktnummer ABIN1944841

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ErbB2/Her2 in WB und DB. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für ErbB2/Her2 Antikörper (pSer1107) (ABIN1944841)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Dot Blot (DB)

Klon: RB40102

Produktdetails anti-ErbB2/Her2 Antikörper

Bindungsspezifität: pSer1107

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1107 of human ERBB2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ErbB2/Her2 Antikörper (ABIN1944841)

Geradts, Bean, Bentley, Barry: "The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." in: Cancer investigation, Vol. 28, Issue 9, pp. 969-77, (2010) (PubMed).

Zaoui, Benseddik, Daou, Salaün, Badache: "ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 43, pp. 18517-22, (2010) (PubMed).

Stackievicz, Paran, Bernheim, Shapira, Weisenberg, Kaufman, Klein, Gutman: "Prognostic significance of HER-2/neu expression in patients with ductal carcinoma in situ." in: The Israel Medical Association journal : IMAJ, Vol. 12, Issue 5, pp. 290-5, (2010) (PubMed).

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: ERBB2

Hintergrund: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Molekulargewicht: 137910

Gen-ID: 2064

NCBI Accession: NP_001005862, NP_004439

UniProt: P04626

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development