Der Kaninchen Polyklonal Anti-TCL1A-Antikörper wurde für WB und FACS validiert. Er ist geeignet, TCL1A in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This TCL1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the Central region of human TCL1A.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Laine, Künstle, Obata, Sha, Noguchi: "The protooncogene TCL1 is an Akt kinase coactivator." in: Molecular cell, Vol. 6, Issue 2, pp. 395-407, (2000) (PubMed).
Virgilio, Narducci, Isobe, Billips, Cooper, Croce, Russo: "Identification of the TCL1 gene involved in T-cell malignancies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 26, pp. 12530-4, (1995) (PubMed).
Fu, Virgilio, Narducci, Facchiano, Russo, Croce: "Characterization and localization of the TCL-1 oncogene product." in: Cancer research, Vol. 54, Issue 24, pp. 6297-301, (1995) (PubMed).
Target
TCL1A
(T-Cell Leukemia/lymphoma 1A (TCL1A))
Andere Bezeichnung
TCL1A
Hintergrund
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.