Presenilin 2 Antikörper (N-Term)

Produktnummer ABIN1944732

Dieses Anti-Presenilin 2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Presenilin 2 in WB und FACS. Geeignet für Human. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für Presenilin 2 Antikörper (N-Term) (ABIN1944732)

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Presenilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: RB30801

Produktdetails anti-Presenilin 2 Antikörper

Bindungsspezifität: AA 32-65, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PSEN2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-65 amino acids from the N-terminal region of human PSEN2(Presenilin-2 NTF subunit).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Presenilin 2 Antikörper (ABIN1944732)

Levy-Lahad, Poorkaj, Wang, Fu, Oshima, Mulligan, Schellenberg: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." in: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).

Li, Ma, Potter: "Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 26, pp. 12180-4, (1996) (PubMed).

Levy-Lahad, Wasco, Poorkaj, Romano, Oshima, Pettingell, Yu, Jondro, Schmidt, Wang: "Candidate gene for the chromosome 1 familial Alzheimer's disease locus." in: Science (New York, N.Y.), Vol. 269, Issue 5226, pp. 973-7, (1995) (PubMed).

Rogaev, Sherrington, Rogaeva, Levesque, Ikeda, Liang, Chi, Lin, Holman, Tsuda: "Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene." in: Nature, Vol. 376, Issue 6543, pp. 775-8, (1995) (PubMed).

Details zu Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Andere Bezeichnung: PSEN2

Hintergrund: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Molekulargewicht: 50140

Gen-ID: 5664

UniProt: P49810

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung