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CD13 Antikörper (APC)

Der Maus Monoklonal Anti-CD13-Antikörper wurde für FACS validiert. Er ist geeignet, CD13 in Proben von Human und Non-Human Primate zu detektieren. Es sind 4+ Publikationen verfügbar.
Produktnummer ABIN192308

Kurzübersicht für CD13 Antikörper (APC) (ABIN192308)

Target

Alle CD13 (ANPEP) Antikörper anzeigen
CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Reaktivität

  • 163
  • 56
  • 27
  • 12
  • 7
  • 7
  • 6
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Non-Human Primate

Wirt

  • 108
  • 63
  • 15
  • 1
  • 1
  • 1
Maus

Klonalität

  • 130
  • 54
  • 1
Monoklonal

Konjugat

  • 85
  • 16
  • 15
  • 12
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD13 Antikörper ist konjugiert mit APC

Applikation

  • 111
  • 60
  • 40
  • 38
  • 37
  • 30
  • 25
  • 17
  • 16
  • 14
  • 13
  • 7
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

WM15
  • Verwendungszweck

    Anti-Hu CD13 APC

    Spezifität

    The antibody WM15 recognises an extracellular epitope of human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.

    Kreuzreaktivität (Details)

    Human, Non-Human Primates

    Aufreinigung

    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    Human AML cells

    Isotyp

    IgG1
  • Applikationshinweise

    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    No reconstitution is necessary.

    Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • McCormack, Muji?, Osdal, Bruserud, Gjertsen: "Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia." in: Blood, Vol. 121, Issue 7, pp. e34-42, (2013) (PubMed).

    Favaloro, Browning, Facey: "CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated." in: Experimental hematology, Vol. 21, Issue 13, pp. 1695-701, (1993) (PubMed).

    Bradstock, Favaloro, Kabral, Kerr, Hughes, Berndt, Musgrove: "Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells." in: Pathology, Vol. 17, Issue 3, pp. 392-9, (1986) (PubMed).

    Bradstock, Favaloro, Kabral, Kerr, Hughes, Musgrove: "Myeloid progenitor surface antigen identified by monoclonal antibody." in: British journal of haematology, Vol. 61, Issue 1, pp. 11-20, (1985) (PubMed).

  • Target

    CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

    Andere Bezeichnung

    CD13

    Hintergrund

    Alanyl aminopeptidase, membrane,CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.,Aminopeptidase N, APN, PEPN, ANPEP, gp150, LAP1

    Gen-ID

    290

    UniProt

    P15144

    Pathways

    Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones
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