SIVA1 Antikörper (N-Term)

Produktnummer ABIN1888008

Dieses Anti-SIVA1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIVA1 in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für SIVA1 Antikörper (N-Term) (ABIN1888008)

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIVA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SIVA1 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of human SIVA.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu SIVA1

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Andere Bezeichnung: SIVA

Hintergrund: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily.SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure.The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway.SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFkappa-B and promotes T-cell receptor-mediated apoptosis.SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.
Synonyms: SIVA1, apoptosis-inducing factor, CD27-binding protein, CD27BP, SIVA-1, SIVA-2

NCBI Accession: NP_068355

Pathways: Positive Regulation of Endopeptidase Activity