MAP3K14 Antikörper (AA 931-947)

Produktnummer ABIN1886903

Produktdetails anti-MAP3K14 Antikörper

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Bindungsspezifität: AA 931-947

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP3K14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Purified by DEAE column

Immunogen: Peptide corresponding to amino acids 931 to 947 of human NIK.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Andere Bezeichnung: NIK (MAP3K14 Produkte)

Synonyme: FTDCR1B antikoerper, HS antikoerper, HSNIK antikoerper, NIK antikoerper, F23F1.4 antikoerper, F23F1_4 antikoerper, mitogen-activated protein kinase kinase kinase 14 antikoerper, Nik antikoerper, aly antikoerper, mitogen-activated protein kinase kinase kinase 14 antikoerper, MAP3K14 antikoerper, Map3k14 antikoerper, MAPKKK14 antikoerper

Hintergrund: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses.NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS and mitogens.A serine/threonine protein kinase which mediates NF-kappaB activation by IL-1, TNFalpha and CD95 was identified recently and designated NIK (for NF-kappaB inducing kinase).NIK is an activator of IkappaB kinase alpha and beta (IKKalpha and IKKbeta).Therefore, NIK is a key molecule in the NF-kappaB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

UniProt: Q99558

Pathways: NF-kappaB Signalweg, T-Zell Rezeptor Signalweg