BNIP3L/NIX Antikörper (AA 77-92)

Produktnummer ABIN1886900

Der Kaninchen Polyklonal Anti-BNIP3L/NIX-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, BNIP3L/NIX in Proben von Human zu detektieren.

Kurzübersicht für BNIP3L/NIX Antikörper (AA 77-92) (ABIN1886900)

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BNIP3L/NIX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-BNIP3L/NIX Antikörper

Bindungsspezifität: AA 77-92

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 77 to 92 of human origin, which are identical to those of mouse Bnip3L.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Andere Bezeichnung: Bnip3L

Hintergrund: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death.Bcl-2 homology 3 (BH3) domain is a potent death domain.BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family.A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3alpha, and Nix (for Nip3-like protein X).Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3.Overexpression of Bnip3L induces apoptosis.Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL.Bnip3L is localized in mitochondria.The messenger RNA of Bnip3L is ubiquitously expressed in human tissues.Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
Synonyms: Nix

Molekulargewicht: 40 kDa

Pathways: Autophagie