Caspase 10 Antikörper (AA 505-521)

Produktnummer ABIN1886883

Dieses Anti-Caspase 10-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Caspase 10 in WB und ELISA. Geeignet für Human.

Kurzübersicht für Caspase 10 Antikörper (AA 505-521) (ABIN1886883)

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Caspase 10 Antikörper

Bindungsspezifität: AA 505-521

Spezifität: Antibody only recognizes FLICE2 form of caspase-10.

Aufreinigung: Purified by DEAE column

Immunogen: Peptide corresponding to amino acids 505 to 521 of human FLICE2.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu Caspase 10

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Andere Bezeichnung: Caspase-10

Hintergrund: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family.A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch4 and renamed as caspase-10.Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors.Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis.Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP.Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death.Caspase-10 is expressed in many tissues and cell lines.
Synonyms: Casp-10, FLICE2

Pathways: Apoptose, Caspase Kaskade in der Apoptose