GFRA2 Antikörper (AA 377-391)

Produktnummer ABIN1886875

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GFRA2 in WB, ELISA und ICC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für GFRA2 Antikörper (AA 377-391) (ABIN1886875)

Target: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFRA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-GFRA2 Antikörper

Bindungsspezifität: AA 377-391

Aufreinigung: Purified by DEAE column

Immunogen: Peptide corresponding to amino acids 377 to 391 of human GFR alpha 2.The amino acid sequences of immunogenic peptide are identical to those of mouse and rat.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu GFRA2

Target: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Andere Bezeichnung: GFR alpha 2

Hintergrund: Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play key roles in the control of vertebrate neuron survival and differentiation.Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN.The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently.NTNRalpha was also termed GDNFRbeta, Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently.GFRalpha-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF.Thus, NTN, GFRalpha-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Synonyms: GFRa-2, GDNFRb, GDNFRbeta

Molekulargewicht: 52 kDa