MTBP Antikörper (AA 122-139)

Produktnummer ABIN1886842

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MTBP in WB, ELISA und ICC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MTBP Antikörper (AA 122-139) (ABIN1886842)

Target: MTBP (MDM2 Binding Protein (MTBP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-MTBP Antikörper

Bindungsspezifität: AA 122-139

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to amino acids 122 to 139 of human MTBP, which differ from the mouse sequence by three amino acids.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu MTBP

Target: MTBP (MDM2 Binding Protein (MTBP))

Andere Bezeichnung: MTBP

Hintergrund: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death.Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered.The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation.P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein.MDM2 inhibits both p53 mediated G1 arrest and apoptosis.A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53.MTBP is expressed in a variety of normal tissues.
Synonyms: MTBP

Molekulargewicht: 104 kDa

NCBI Accession: NP_071328