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MTBP Antikörper (MDM2 Binding Protein) AA 667-812 Primary Antibody

MTBP Reaktivität: Human ELISA, WB Wirt: Maus Monoclonal PHL-1 unconjugated
Produktnummer ABIN129549
$658.50
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle MTBP Antikörper anzeigen
    MTBP
    Bindungsspezifität
    • 15
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 667-812
    Reaktivität
    • 43
    • 20
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 43
    • 1
    Maus
    Klonalität
    • 43
    • 1
    Monoklonal
    Konjugat
    • 24
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTBP Antikörper ist unkonjugiert
    Applikation
    • 24
    • 14
    • 13
    • 13
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB)
    Kreuzreaktivität
    Schimpanse
    Aufreinigung
    ASCITES
    Immunogen
    This protein A purified monoclonal antibody was produced by repeated immunizations with a recombinant amino-terminal HIS6X-tagged polypeptide corresponding to amino acid residues 667-812 of human MTBP protein.
    Klon
    PHL-1
  • Applikationshinweise
    This antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 110 kDa in size corresponding to MTBP by western blotting in the appropriate cell lysate or extract.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Target
    MTBP
    Andere Bezeichnung
    MTBP (MTBP Produkte)
    Synonyme
    MDM2BP, AI429604, MDM2 binding protein, Mdm2, transformed 3T3 cell double minute p53 binding protein, MTBP, Mtbp
    Hintergrund
    The MDM2 onco-protein is over expressed in human cancer cells and it promotes tumorigenesis by directly blocking the function of the p53 tumor suppressor.  Studies also indicate that MDM2 regulates cell prolifer-ation via p53 independent mechanisms.   MTBP (Mdm2 [Two] Binding Protein) was identified by a yeast two-hybrid screen as an MDM2 binding protein (1).  MTBP has been reported to modulate cell cycle progression by a p53 independent mechanism and suppress MDM2-mediated p53 degradation when ectopically expressed in cells (1,2).   The human MTBP gene localizes to 8q24 (3) and MTBP RNA is expressed in a wide range of tissues, with highest being in the thymus, testes and ovaries (1).
    Synonyms: MDM 2 BP antibody, MDM2 (mouse double minute 2) binding protein 104kD antibody, MDM2 (mouse double minute 2) binding protein antibody, MDM2 Binding Protein antibody, MDM2 BP antibody
    Gen-ID
    27085
    NCBI Accession
    NP_071328
    UniProt
    Q96DY7
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