Ki-67 Antikörper (N-Term)

Produktnummer ABIN1886792

Der Kaninchen Polyklonal Anti-Ki-67-Antikörper wurde für IHC, IF und ICC validiert. Er ist geeignet, Ki-67 in Proben von Human zu detektieren.

Kurzübersicht für Ki-67 Antikörper (N-Term) (ABIN1886792)

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ki-67 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-Ki-67 Antikörper

Bindungsspezifität: N-Term

Immunogen: KLH conjugated synthetic peptide derived from human Ki67 N-terminus

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.100-1.500
Immunohistochemistry 1.100-1.500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M PBS, pH 7.4 with 10 mg/ml BSA and 0.1 % Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C/1 year

Haltbarkeit: 12 months

Details zu Ki-67

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Andere Bezeichnung: Ki67

Hintergrund: Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase).It is absent in resting (G0) cells.Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index).In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index.The correlation between low Ki67 index and histologically low grade tumours is strong.Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.Sueishi M.et al.J.Biol.Chem.275:28888-28892(2000) Takagi M.et al.J.Biol.Chem.276:25386-25391(2001) Beausoleil S.A.et al.Proc.Natl.Acad.Sci.U.S.A.101:12130-12135(2004) Olsen J.V.et al.Cell 127:635-648(2006)
Synonyms: KIA, Ki-67, Ki67, MKI67

Molekulargewicht: 358 kDa

UniProt: P46013

Pathways: Glycosaminoglycan Metabolic Process