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Ki-67 Antikörper (AA 2860-3256)

MKI67 Reaktivität: Human WB, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044570
  • Target Alle Ki-67 (MKI67) Antikörper anzeigen
    Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
    Bindungsspezifität
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 12
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2860-3256
    Reaktivität
    • 215
    • 96
    • 61
    • 16
    • 15
    • 5
    • 2
    • 2
    • 1
    Human
    Wirt
    • 158
    • 52
    • 12
    • 3
    Kaninchen
    Klonalität
    • 149
    • 74
    Polyklonal
    Konjugat
    • 96
    • 15
    • 14
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser Ki-67 Antikörper ist unkonjugiert
    Applikation
    • 92
    • 88
    • 67
    • 65
    • 55
    • 52
    • 42
    • 33
    • 29
    • 16
    • 15
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Antigen KI-67(MKI67) detection. Tested with WB, IHC-P, ICC in Human.
    Marke
    Picoband™
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Antigen KI-67(MKI67) detection. Tested with WB, IHC-P, ICC in Human.
    Gene Name: antigen identified by monoclonal antibody Ki-67
    Protein Name: Antigen KI-67
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human Ki67 recombinant protein (Position: K2860-I3256).
    Isotyp
    IgG
    Top Product
    Discover our top product MKI67 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Ki67 is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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    Pan, Tian, Zhang, Zhang, Shi, Liang, Wu, Li, You, Yang, Mao, Qian, Xu: "YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression." in: International journal of oncology, Vol. 51, Issue 4, pp. 1055-1066, (2018) (PubMed).

    Shi, Lv, Nie, Lu, Liu, Tian, Li, Zhang, Ren, Zhang, Kang: "Human nail stem cells are retained but hypofunctional during aging." in: Journal of molecular histology, Vol. 49, Issue 3, pp. 303-316, (2018) (PubMed).

    Ling, Guan, You, Wang, Hu, Zhang, Wang, Chen, Xu, Chen: "Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo." in: OncoTargets and therapy, Vol. 11, pp. 2735-2743, (2018) (PubMed).

    Sun, Zhang, Wang, Shang, Zhou, Wang, Duan, Ruan, Gao, Dai, Qu, Liu, Ding, Wang, Wang, Dou: "MicroRNA-150 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting the GAB1-ERK axis." in: Oncotarget, Vol. 7, Issue 10, pp. 11595-608, (2017) (PubMed).

    Zhou, Wang, Xu, Wan, Qu, Fan, Chen, Sun, Liu: "Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo." in: Oncotarget, Vol. 7, Issue 14, pp. 18620-30, (2017) (PubMed).

    Jiang, He, Wang, Zhang, Zhang, Yan, Wang, Che, Ke, Chen, Tong, Zhang, Wang, Li, Wan: "Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing." in: Oncotarget, Vol. 6, Issue 42, pp. 44660-74, (2016) (PubMed).

    Gao, Shen, He, Xiao: "GNRs@SiO₂-FA in combination with radiotherapy induces the apoptosis of HepG2 cells by modulating the expression of apoptosis-related proteins." in: International journal of molecular medicine, Vol. 36, Issue 5, pp. 1282-90, (2016) (PubMed).

    Han, Wu, Wu, Huang, Cheng, Li, Sun, Xie, Zhou, Du: "Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling." in: Cell death & disease, Vol. 7, pp. e2123, (2016) (PubMed).

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    Alsaegh, Miyashita, Zhu: "Expression of human papillomavirus is correlated with Ki-67 and COX-2 expressions in keratocystic odontogenic tumor." in: Pathology oncology research : POR, Vol. 21, Issue 1, pp. 65-71, (2015) (PubMed).

    Li, Wang, Wu, Yang, Zhao, Chen, Xie, Li, Wei, Huang, Zhou, Du: "miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells." in: Cellular and molecular neurobiology, Vol. 35, Issue 5, pp. 679-87, (2015) (PubMed).

    Liu, Wang, Wang: "Controllable organization and high throughput production of recoverable 3D tumors using pneumatic microfluidics." in: Lab on a chip, Vol. 15, Issue 4, pp. 1195-204, (2015) (PubMed).

    Huang, Ma, Xu, Li, Li, Yue, Li, Guo, Qi: "Wnt2 promotes non-small cell lung cancer progression by activating WNT/?-catenin pathway." in: American journal of cancer research, Vol. 5, Issue 3, pp. 1032-46, (2015) (PubMed).

    Cheng, Wang, Li, Wu, Han, Li, Chen, Xie, Huang, Du, Zhou: "MicroRNA-184 inhibits cell proliferation and invasion, and specifically targets TNFAIP2 in Glioma." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 27, (2015) (PubMed).

    Xie, Zhu, Yang, Huang, Wu, Wang, Luo, Wang, Shao: "Solamargine triggers hepatoma cell death through apoptosis." in: Oncology letters, Vol. 10, Issue 1, pp. 168-174, (2015) (PubMed).

    Yu, Chen, Su, Huo, Lin, Liao: "Factors influencing improvement of visual field after trans-sphenoidal resection of pituitary macroadenomas: a retrospective cohort study." in: International journal of ophthalmology, Vol. 8, Issue 6, pp. 1224-8, (2015) (PubMed).

    Shan, Li, Newton, Zhao, Li, Guo: "A novel protein extracted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells." in: Toxicology letters, Vol. 227, Issue 2, pp. 129-38, (2014) (PubMed).

  • Target
    Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
    Andere Bezeichnung
    MKI67 (MKI67 Produkte)
    Synonyme
    MKI67 antikoerper, kia antikoerper, mki67 antikoerper, MGC132156 antikoerper, D630048A14Rik antikoerper, Ki-67 antikoerper, Ki67 antikoerper, KIA antikoerper, MIB-1 antikoerper, marker of proliferation Ki-67 antikoerper, marker of proliferation Ki-67 L homeolog antikoerper, marker of proliferation Ki-67 S homeolog antikoerper, antigen identified by monoclonal antibody Ki 67 antikoerper, antigen identified by monoclonal antibody Ki-67 antikoerper, nucleolar protein interacting with the FHA domain of MKI67 antikoerper, MKI67 antikoerper, mki67 antikoerper, mki67.L antikoerper, mki67.S antikoerper, Mki67 antikoerper, NIFK antikoerper
    Hintergrund
    Ki-67(Proliferation-related Ki-67 antigen), also known as MKI67 or KIA, is a protein that in humans is encoded by the MKI67 gene. From study of a panel of human-rodent somatic cell hybrids, it has been demonstrated that a gene involved in the expression of the MKI67 antigen is located on chromosome 10. By in situ hybridization, Fonatsch et al. (1991) regionalized the MKI67 gene to chromosome 10q25-qter. By FISH, Traut et al. (1998) mapped the mouse Mki67 gene to chromosome 7F3-F5. Antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore it is associated with ribosomal RNA transcription. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis.

    Synonyms: Antigen identified by monoclonal antibody Ki 67 antibody|Antigen KI-67 antibody|Antigen KI67 antibody|KI67_HUMAN antibody|KIA antibody|MKI67 antibody|Proliferation related Ki 67 antigen antibody|RP11-380J17.2 antibody
    Gen-ID
    4288
    UniProt
    P46013
    Pathways
    Glycosaminoglycan Metabolic Process
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