MCM3 Antikörper (AA 42-272)

Produktnummer ABIN1886459

Der Kaninchen Polyklonal anti-MCM3 Antikörper wird verwendet zum Nachweis von MCM3 in Proben von Human. Er wurde validiert für WB, IHC und IF.

Kurzübersicht für MCM3 Antikörper (AA 42-272) (ABIN1886459)

Target: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-MCM3 Antikörper

Bindungsspezifität: AA 42-272

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 42 and 272 of MCM3

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500
Immunofluorescence: 1.100-1.200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu MCM3

Target: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Andere Bezeichnung: MCM3

Hintergrund: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication.The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.This protein is a subunit of the protein complex that consists of MCM2-7.It has been shown to interact directly with MCM5/CDC46.This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase.The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.[provided by RefSeq]

Molekulargewicht: 91 kDa

Gen-ID: 4172

NCBI Accession: NM_002388, NP_002379

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA