C5 Antikörper (AA 1223-1421)

Produktnummer ABIN1885991

Der Kaninchen Polyklonal Anti-C5-Antikörper wurde für WB und IHC validiert. Er ist geeignet, C5 in Proben von Human zu detektieren.

Kurzübersicht für C5 Antikörper (AA 1223-1421) (ABIN1885991)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-C5 Antikörper

Bindungsspezifität: AA 1223-1421

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1223 and 1421 of Human C5

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu C5

Target: C5 (Complement Component 5 (C5))

Hintergrund: The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes.This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge.An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase.The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections.Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.[provided by RefSeq]

Molekulargewicht: 188 kDa

Gen-ID: 727

NCBI Accession: NM_001735, NP_001726

Pathways: Komplementsystem, Carbohydrate Homeostasis