LEF1 Antikörper (Lymphoid Enhancer-Binding Factor 1) (AA 10-37)

Details for Product anti-LEF1 Antibody No. ABIN1882259, Anbieter: Anmelden zum Anzeigen
Antigen
  • LEF1
  • 3000002B05
  • AI451430
  • Lef-1
  • LEF-1
  • TCF10
  • TCF1ALPHA
  • TCF7L3
  • lymphoid enhancer binding factor 1
  • lymphoid enhancer-binding factor 1
  • lymphoid enhancer factor XLEF-1B
  • LEF1
  • lef1
  • Lef1
Epitop
AA 10-37
14
12
12
10
8
8
6
6
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
145
52
37
11
7
7
7
5
5
4
4
4
3
2
1
1
Wirt
Maus
67
57
17
5
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser LEF1 Antikörper ist unkonjugiert
4
4
4
3
3
3
Applikation
Western Blotting (WB)
132
81
29
24
9
9
5
5
3
2
2
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This LEF1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 10-37 amino acids from human LEF1.
Klon 661CT8-3-5
Isotyp IgG1
Homologie Mouse (Murine),Rat (Rattus)
Reinigung Ascites
Plasmids, Primers & others Plasmide, Primers & weitere LEF1 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung LEF1 (LEF1 Antibody Abstract)
Hintergrund This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Synonyms: LEF1, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha
NCBI Accession NP_001124185, NP_057353, NP_001159591, NP_001124186
UniProt Q9UJU2
Pathways WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding
Applikations-hinweise WB: 1:500-8000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Bilder des Herstellers
Western Blotting (WB) image for anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 10-37) antibody (ABIN1882259) LEF1 Antibody (ABIN1882259) western blot analysis in K562 cell line lysates (35 µg/la...
Produkt verwendet in: Gutierrez, Tschumper, Wu, Shanafelt, Eckel-Passow, Huddleston, Slager, Kay, Jelinek: "LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis." in: Blood, Vol. 116, Issue 16, pp. 2975-83, 2010 (PubMed).

Kalsi, Kuo, Aliev, Alexander, McMichael, Patterson, Walsh, Zhao, Schuckit, Nurnberger, Edenberg, Kramer, Hesselbrock, Tischfield, Vladimirov, Prescott, Dick, Kendler, Riley: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." in: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, 2010 (PubMed).

Chen, Zhang, Pincus, Wu, Ricks, Liu, Sun, Maclaren, Lan: "Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 9, pp. 5047-54, 2010 (PubMed).

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