Filamin A Antikörper (AA 1-360)

Produktnummer ABIN1882243

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Filamin A in WB. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für Filamin A Antikörper (AA 1-360) (ABIN1882243)

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Filamin A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1273CT424-104-153

Produktdetails anti-Filamin A Antikörper

Bindungsspezifität: AA 1-360

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified His-tagged FLNA protein was used to produced this monoclonal antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Filamin A Antikörper (ABIN1882243)

Campos, Rodriguez, Machado Leopoldino, Hait, Lopez Bergami, Castro, Sanchez, Maceyka, Spiegel, Alvarez: "Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-?B Activation in Melanoma Cells by Inhibition of Akt Signaling." in: Molecular and cellular biology, (2015) (PubMed).

Li, Liu, Wang, Liu, Liu, Li, Wan, Wang, Zhang, Jin, Liu, Zhu, Liu: "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 11, pp. 2517-28, (2010) (PubMed).

Chen, Zollo, Mazzarella, Ciccodicola, Chen, Zuo, Heiner, Burough, Repetto, Schlessinger, DUrso: "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci." in: Human molecular genetics, Vol. 5, Issue 5, pp. 659-68, (1997) (PubMed).

Patrosso, Repetto, Villa, Milanesi, Frattini, Faranda, Mancini, Maestrini, Toniolo, Vezzoni: "The exon-intron organization of the human X-linked gene (FLN1) encoding actin-binding protein 280." in: Genomics, Vol. 21, Issue 1, pp. 71-6, (1994) (PubMed).

Gorlin, Yamin, Egan, Stewart, Stossel, Kwiatkowski, Hartwig: "Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring." in: The Journal of cell biology, Vol. 111, Issue 3, pp. 1089-105, (1990) (PubMed).

Details zu Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Andere Bezeichnung: FLNA

Hintergrund: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.

Molekulargewicht: 280739

NCBI Accession: NP_001104026, NP_001447

UniProt: P21333

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location